PT  - JOURNAL ARTICLE
AU  - Penha, Fabianna Acerbi
AU  - Penha, Giovanna Acerbi
AU  - Acerbi, Helena Maria Caleiro
TI  - A Comprehensive Literature Review: The Potential of Exosomes in Hair Growth and Transplantation
AID  - 10.33589/35.3.73
DP  - 2025 May 01
TA  - International Society of Hair Restoration Surgery
PG  - 73--84
VI  - 35
IP  - 3
4099  - http://www.ISHRS-HTForum.org/content/35/3/73.short
4100  - http://www.ISHRS-HTForum.org/content/35/3/73.full
AB  - Exosomes, small extracellular vesicles secreted by various cell types, have gained attention in regenerative medicine, particularly for hair growth and dermatological applications. Containing bioactive molecules like microRNAs, growth factors, and proteins, exosomes regulate cellular processes and promote hair follicle regeneration. Derived from mesenchymal stem cells, exosomes increase dermal papilla cell proliferation and modulate inflammation and oxidative stress in the scalp, fostering a better environment for hair growth. They also promote angiogenesis, ensuring blood supply to hair follicles. Exosomes are being studied for their potential to treat alopecia, scalp disorders, and wound healing, owing to their ability to modulate immune responses and tissue regeneration.A search of PubMed and Cochrane revealed promising results, though more clinical studies are needed to assess their safety and effectiveness. Exosomes show potential for improving skin health and treating hair loss, and further research may lead to innovative therapies for various dermatological conditions.