Colonization
(Recommended only for HCP implicated in case cluster, outbreaks, or high-risk patients.) | Nasal Mupiricin ointment bid for 5 days, plus, Trimehtoprim/sulfa double strength po bid for 10 days Or, Minocycline or doxycylcine 100 mg po bid 10 days, plus, Providine/iodine baths for 3 days
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| Superficial colonization of a wound without signs of infection | Regular cleaning with Hibiclens Topical application of silver dressing with activity against MRSA (Acticoat or Silvasorb) or Mupiricin ointment Close monitoring for signs of infection
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Superficial skin and soft tissue infection cellulitis (HA or CA MRSA)
(Antibiotic choice should be determined by local resistance patterns.) | Local wound cleaning and debridement Topical Mupiricin Trimehtoprim/sulfa double strength po bid for at least 10 days Or, Minocycline or doxycylcine 100 mg po bid for at least 10 days Plus, Rifampin 300mg po bid X 5 days If failure of above measures, Infectious Disease consult Zyvox (linezolid) 600mg po Q12h (monitor for myelosuppression if longer than 10 days
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Complex skin and skin structure infection
(Antibiotic choice should be determined by local resistance patterns.) | Aggressive debridement essential Topical Mupiricin Trimehtoprim/sulfa double strength po bid for at least 10 days Or, Minocycline or doxycylcine 100 mg po bid for at least 10 days Plus, Rifampin 300mg po bid X 5 days If failure of above measures, or known HA-MRSA Infectious Disease consult Zyvox(linezolid) 600mg po Q12h or vancomycin iv
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