Table 1.

Mechanisms of PFS (Credit: Alan Jacobs, MD. “Post-Finasteride Syndrome and the Neuroendocrine System.” Presented at the ISHRS 24th World Congress, Las Vegas, Nevada, USA. September 2016.)

Mechanisms of PFS
1. Testicular functioning is normal.
2. The pituitary gonadotrophs function normally.
3. The hypothalamic GnRH cells may be the area of dysfunction.
4. The temporal lobe limbic structures often inhibit hypothalamic GnRH function.