Background Insulin-like growth factor-I (IGF-I) shares a high degree of structural and
functional homology with insulin and is a potent mitogen supporting cell growth and survival in …

Shikimic acid (SA) has recently been found to be a major component of plant stem cells. The
exact effects of SA on human hair follicles (HFs) is unknown. The purpose of this study was …

Glucocorticoid (GC) is synthesized mostly in the adrenal gland and is secreted in response
to stressful conditions. The stress-induced increase in systemic GC may mediate diverse …

Background Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects
for patients undergoing chemotherapy. This study evaluated the protective effect of Korean …

Background Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular
level of cyclic adenosine monophosphate to cause vasodilation. Topical application of …

Background Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, is known to increase the
intracellular level of cyclic guanosine monophosphate (cGMP), which causes vasodilation. …

The hair follicle is a widely available and instructive miniature organ in the human body that
experiences major histocompatibility complex (MHC) class I dependent immune privilege (IP…

Introduction Hair loss is a common phenomenon associated with various environmental and
genetic factors. Mitochondrial dysfunction-induced oxidative stress has been recognized as …

Discussion Hair transplantation, as originally described by Okuda and Orentreich, 1, 4, 5
involves the removal of hair bearing grafts from the occiput and transplanting in another area of …

Corticotropin-releasing hormone (CRH) is a key mediator in stress-induced hair growth
inhibition. Here, we investigated the impact of stress-induced senescence and evaluated the …