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Long-Term (Over 10 Years) Evaluation of Efficacy and Safety of Finasteride in Japanese Men with Androgenetic Alopecia: Summary of Three Investigations

Masayuki Yanagisawa and Akio Sato
Hair Transplant Forum International July 2022, 32 (4) 130-132; DOI: https://doi.org/10.33589/32.4.130
Masayuki Yanagisawa
Tokyo, Japan
MD, PhD
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  • For correspondence: yanagisaw@hotmail.com
Akio Sato
Tokyo, Japan
MD, PhD
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Abstract

Introduction: Finasteride has been the standard medical treatment for androgenetic alopecia (AGA) for over 20 years. We started AGA treatment with finasteride in 1999 in Japan, and have demonstrated 3 investigations as long-term and/or large-scale studies (3,177 cases in 2.5 years, 801 cases in 5 years, 532 cases in 10 years, respectively). The objective of this study is to summarize the three investigations, and to consider it as a base for future studies over the next 20 to 30 or more years.

Methods: Vertex photographs and/or forehead photographs were taken and recorded for every patient at each examination and used for evaluation for more than 20 years. Efficacy was assessed using the Norwood-Hamilton scale (N-H) and the modified global photographic assessment (MGPA) score, which is the standardized 7-point rating score using scalp photographs. Adverse reactions were assessed through self-reported evaluations by patients in two investigations

Results: All three of the investigations demonstrated high evaluations of improvement (MGPA≧5; 87.1%, 99.4%, and 91.5%, respectively), and higher evaluations of prevention of disease progression (MGPA≧4; 99.6%, 100%, and 99.1%, respectively). Furthermore, the early-stage AGA group (N-H I-III at first visit) and the younger group (less than 40 years of age at first visit) showed more improvement with long-term AGA treatment with finasteride than the other groups did. Two of the investigations showed safety of long-term AGA treatment with finasteride, revealing the low onset rates of adverse reactions (adverse reactions: 0.7% in 2.5 years and 6.8% in 10 years, respectively). Neither of the two investigations recognized Post Finasteride Syndrome adverse reaction at all.

Conclusion: Long-term (greater than 10 years) AGA treatment with finasteride 1 mg/day demonstrated a high efficacy and safety based on large-scale studies in Japanese men. For patients at the early stage of classification of AGA (within N-H I-III or earlier) and/or younger than 40 years of age, we recommend starting treatment with 1 mg/day finasteride.

  • androgenetic alopecia
  • finasteride
  • Japanese
  • modified global photographic assessment score
  • Norwood-Hamilton scale
  • Copyright © 2022 by the International Society of Hair Restoration Surgery

This article is open access and may not be copied, distributed, or modified without written permission from the International Society of Hair Restoration Surgery.

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International Society of Hair Restoration Surgery: 32 (4)
Hair Transplant Forum International
Vol. 32, Issue 4
July/August 2022
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Long-Term (Over 10 Years) Evaluation of Efficacy and Safety of Finasteride in Japanese Men with Androgenetic Alopecia: Summary of Three Investigations
Masayuki Yanagisawa, Akio Sato
Hair Transplant Forum International Jul 2022, 32 (4) 130-132; DOI: 10.33589/32.4.130

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Long-Term (Over 10 Years) Evaluation of Efficacy and Safety of Finasteride in Japanese Men with Androgenetic Alopecia: Summary of Three Investigations
Masayuki Yanagisawa, Akio Sato
Hair Transplant Forum International Jul 2022, 32 (4) 130-132; DOI: 10.33589/32.4.130
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Keywords

  • androgenetic alopecia
  • finasteride
  • Japanese
  • modified global photographic assessment score
  • Norwood-Hamilton scale

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