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Research ArticleArticles
Open Access

A Retrospective Study on the Safety of Systemic Minoxidil for Hair Loss in the Older Population

Blythe Ke and Damkerng Pathomvanich
Hair Transplant Forum International November 2024, 34 (6) 206-209; DOI: https://doi.org/10.33589/34.6.206
Blythe Ke
Manila, Philippines
MD
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  • For correspondence: blythe.ke@gmail.com
Damkerng Pathomvanich
Bangkok, Thailand
MD, FISHRS
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ABSTRACT

Oral or systemic minoxidil has been used off-label for decades to treat androgenetic alopecia (AGA) and other hair loss disorders. Its adverse effects have been reported in the literature to include facial and body hypertrichosis, palpitations, and fluid retention, among others. Most safety studies on low-dose systemic minoxidil for the indication of hair loss have been comprised of the younger population; however, for this retrospective study, we have chosen to look at adverse events in the older population (aged 60 years and above), taking into account the group’s possibly higher presence of comorbid conditions and/or intake of other medications.

Among 42 patients, only 19% had experienced adverse events, with facial and body hypertrichosis being the most common. Adverse events were managed successfully by dose reduction, leg elevation, salt restriction, and diuretics, and only 2 had to discontinue minoxidil. No serious adverse events were found in the study. While no diagnostic evaluation is required for healthy patients in this age group, we highly recommend caution when prescribing systemic minoxidil for patients on multiple antihypertensives agents and for those at risk for cardiovascular events.

Keywords:
  • alopecia
  • androgenetic alopecia
  • hair loss
  • minoxidil
  • Copyright © 2024 by the International Society of Hair Restoration Surgery

This article is open access and may not be copied, distributed, or modified without written permission from the International Society of Hair Restoration Surgery.

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International Society of Hair Restoration Surgery: 34 (6)
Hair Transplant Forum International
Vol. 34, Issue 6
November/December 2024
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A Retrospective Study on the Safety of Systemic Minoxidil for Hair Loss in the Older Population
Blythe Ke, Damkerng Pathomvanich
Hair Transplant Forum International Nov 2024, 34 (6) 206-209; DOI: 10.33589/34.6.206

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A Retrospective Study on the Safety of Systemic Minoxidil for Hair Loss in the Older Population
Blythe Ke, Damkerng Pathomvanich
Hair Transplant Forum International Nov 2024, 34 (6) 206-209; DOI: 10.33589/34.6.206
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Keywords

  • alopecia
  • androgenetic alopecia
  • hair loss
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