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Research ArticleArticles
Open Access

A Comprehensive Literature Review: The Potential of Exosomes in Hair Growth and Transplantation

Fabianna Acerbi Penha, Giovanna Acerbi Penha and Helena Maria Caleiro Acerbi
Hair Transplant Forum International May 2025, 35 (3) 73-84; DOI: https://doi.org/10.33589/35.3.73
Fabianna Acerbi Penha
São Paulo, Brasil
MD
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  • For correspondence: acerbipenhafabi@gmail.com
Giovanna Acerbi Penha
São Paulo, Brasil;
MD
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Helena Maria Caleiro Acerbi
São Paulo, Brasil
PhD
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Article Figures & Data

Figures

  • FIGURE 1.
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    FIGURE 1.

    Release of microvesicles and exosomes. Note the clathrin associated with vesicles at the plasma membrane (clathrin-coated vesicles - CCV), or bilayered clathrin coats at endosomes. The arrows represent the direction of transport of lipids and proteins between organelles and MVEs, and the direction of secretion of exosomes. CCV = clathrin-coated vesicles; MVE = multivesicular endosome; ER = endoplasmic reticulum.

  • FIGURE 2.
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    FIGURE 2.

    Numerous molecules enrich exosomes.

  • FIGURE 3.
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    FIGURE 3.

    Some potential applications of exosomes in dermatology.

  • FIGURE 4.
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    FIGURE 4.

    Exosomes anti-inflammatory effects on skin diseases.

  • FIGURE 5.
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    FIGURE 5.

    Exosomes can stimulate hair follicle cells and promote the proliferation of new hair.

  • FIGURE 6.
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    FIGURE 6.

    Isolation of mesenchymal stem cells exosomes.

  • FIGURE 7.
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    FIGURE 7.

    The hair follicle and shaft growth cycle.

  • FIGURE 8.
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    FIGURE 8.

    Combination of platelet-rich plasma and exosomes in hair transplantation.

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In this issue

International Society of Hair Restoration Surgery: 35 (3)
Hair Transplant Forum International
Vol. 35, Issue 3
May/June 2025
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A Comprehensive Literature Review: The Potential of Exosomes in Hair Growth and Transplantation
Fabianna Acerbi Penha, Giovanna Acerbi Penha, Helena Maria Caleiro Acerbi
Hair Transplant Forum International May 2025, 35 (3) 73-84; DOI: 10.33589/35.3.73

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A Comprehensive Literature Review: The Potential of Exosomes in Hair Growth and Transplantation
Fabianna Acerbi Penha, Giovanna Acerbi Penha, Helena Maria Caleiro Acerbi
Hair Transplant Forum International May 2025, 35 (3) 73-84; DOI: 10.33589/35.3.73
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  • Article
    • ABSTRACT
    • INTRODUCTION
    • BIOGENESIS AND COMPOSITION OF EXOSOMES
    • INTERCELLULAR EXCHANGE OF EXOSOMES
    • ROLE OF EXOSOMES IN IMMUNE REGULATION
    • THERAPEUTIC POTENTIAL OF EXOSOMES IN DERMATOLOGY
    • MODERATING FACTORS OF EXOSOME ACTIVITY IN DERMATOLOGY
    • SOURCE AND ISOLATION METHOD
    • DOSE AND ADMINISTRATION
    • EXOSOME RECEPTORS ON TARGET CELLS
    • ANALYSIS AND CHARACTERIZATION OF EXOSOMES
    • EXOSOMES PROMOTE HAIR GROWTH
    • POTENTIAL LIMITATIONS OF EXOSOME THERAPY IN HAIR TRANSPLANTATION
    • CONCLUSION
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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Keywords

  • exosome
  • hair growth

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